DNA LIGASE

Specialty Definition: Ligase

(From Wikipedia, the free Encyclopedia)

A Ligase is an enzyme that can ligate ("glue together") two molecules with a covalent bond, using energy from ATP.
DNA ligase can ligate broken DNA strands, forming covalent phosphodiester bonds.
An example of how a ligase works (with sticky ends):
5'-AGTCTGATCTGACT        GATGCGTATGCTAGTGCT-3'
3'-TCAGACTAGACTGACTACG        CATACGATCACGA-5'
becomes
5'-AGTCTGATCTGACTGATGCGTATGCTAGTGCT-3'
3'-TCAGACTAGACTGACTACGCATACGATCACGA-5'Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Ligase."

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