MAXIMUM TOLERATED DOSE

Domain	Definition
Agriculture	Loosely, the highest dose of a chemical that when administered to a group of test animals does not increase the death rate during a long-term study. The purpose of administering MTD is to determine whether long-term exposure to a chemical might lead to any adverse health effects in a population, when the level of exposure is not sufficient to cause premature mortality due to short-term toxic effects. The maximum dose is used, rather than a lower dose, to reduce the number of animals that need to be tested (and thus, the cost of animal testing), in order to detect an effect that occurs only rarely. This analysis is used in establishing chemical residue tolerances in foods. (MTD). (references)
Environment	The maximum dose that an animal species can tolerate for a major portion of its lifetime without significant impairment or toxic effect other than carcinogenicity. (references)
Medicine	The highest dose level eliciting signs of toxicity without having major effects on survival relative to the test in which it is used. Source: European Union. (references)
Source: compiled by the editor from various references; see credits.

Language		Translations for "MAXIMUM TOLERATED DOSE"; alternative meanings/domain in parentheses.
Danish		MTD, maksimal tolereret dosis, Maksimal Tolerabel Dosis. (various references)

Dutch		MTD, maximale dosis, maximaal te verdragen dosis. (various references)

Finnish		suurin siedetty annos. (various references)

French		Dose Maximale Tolérable, dose maximale tolérée (maximum permissible dose, maximum recommended dose), DMT. (various references)

German		MTD, maximal verträgliche Dosis, Einzelmaximaldosis. (various references)

Greek		MTD, μέγιστη ανεκτή δόση, DMT. (various references)

Italian		Dose Massima Tollerata, DMT. (various references)

Pig Latin		aximummay oleratedtay oseday

Portuguese		Dose Máxima Tolerada, DMT. (various references)

Spanish		dosis maxima tolerable, Dosis Máxima Tolerable, DMT. (various references)
Source: compiled by the editor from various translation references.

Specialty Definition: MAXIMUM TOLERATED DOSE